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院长助理 张峰
发布时间:2015-5-6 13:02:16  浏览次数: 次  来源:本站



张 峰 博士
副教授 博士生导师
陕西省青年科技新星

主要从事分子流行病学与医学统计学研究。2010年至今,先后主持国家自然科学基金项目2项、省部级项目6项,以第二及第三完成人参与国家自然科学基金项目3项。截至目前,已发表SCI论文37篇,其中第一作者SCI论文18篇,4篇第一作者论文先后被国际一流学术期刊《Proc Natl Acad Sci U S A》、《Nature Reviews Genetics》 和《ENDOCRINE REVIEWS》的文章引用。申请国家发明专利2项,参编学术专著1本(编委)。 2007年国家公派赴University of Missouri-Kansas City访问学习,2005年赴Creighton University访问学习。 2013年入选“陕西省青年科技新星”,2013年获陕西省科学技术奖一等奖(第十完成人)。目前兼任中国环境诱变剂学会风险评价专业委员会委员、陕西省医学会风湿病学分会委员。

联系方式:
地址:西安交通大学医学部公共卫生学院(西安市雁塔西路76号)
邮编:710061
电话:029-82655229,传真:029-82655332
E-mail:fzhxjtu@mail.xjtu.edu.cn


发表论文:
1. Zhang F, Wen Y, Guo X, Zhang Y, Wang X, Yang TL, et al. Genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese. Arthritis & Rheumatology, doi: 10.1002/art.38898(SCI,IF: 7.87)
2. Zhang F, Wen Y, Guo X. CRISPR/Cas9 for genome editing: progress, implications and challenges. Hum Mol Genet. 2014 ;23(R1):R40-R46 (SCI,IF: 6.68)
3. Zhang F, Guo X, Zhang Y, Wen Y,Wang WZ, Wang S, Yang TL, et al. Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease. Hum Genet. 2014 Jun;133(6):793-9(SCI,IF: 4.52)
4. Zhang F, Guo X, Wen Y, Zhang Y, Wang S, Yang TL, et al. Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese. Bone, 2014, accept(SCI,IF: 4.46)
5. Zhang F, Xiao P, Yang F, Shen H, Xiong DH, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. A whole genome linkage scan for QTLs underlying peak bone mineral density. Osteoporosis International. 2008 Mar;19(3):303-310.(SCI,IF: 4.89)
6. Zhang F, Liang J, Guo X, Zhang Y, Wen Y, Li Q, Zhang Z, Ma W, Dai L, Liu X, Yang L, Wang J. Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromas. PLoS One. 2013 Aug 29;8(8):e72316.(SCI,IF: 3.79)
7. Zhang F, Guo X, Deng HW. Multilocus Association Testing of Quantitative Traits based on Partial Least-squares Analysis. PLoS ONE.2011 Feb;6(2):e16739.(SCI,IF: 4.09)
8. Zhang F, Guo X, Duan C, Wu SX, Yu, HJ, Lammi M. Identification of Differently Expressed Genes and Pathways Between Primary Osteoarthritis and Endemic Osteoarthritis Kashin-Beck Disease. Scand J Rheumatol. 2013 Jan;42(1),71-9(SCI,IF: 2.24)
9. Zhang F, Wen Y, Guo X, Yang TL, Hui S, et al. Trans-omics pathway analysis suggest eQTLs contribute to chondrocyte apoptosis of Kashin-Beck disease through regulating apoptosis pathway expression. Gene, 2014, accept. (SCI, IF:2.08 )
10. Zhang F, Guo X, Wang WZ, Yan H, Li CY. Genome-Wide Gene Expression Analysis Suggests an Important Role of Hypoxia in the Pathogenesis of Endemic Osteochondropathy Kashin-Beck Disease. PLoS ONE. 2011 Jul;6(7):e22983.(SCI,IF: 4.09)
11. Zhang F, Deng HW. Confounding from Cryptic Relatedness in Haplotype-based Association Studies. Genetica.2010 Oct; 138(9-10):945–950.(SCI,IF: 2.36)
12. Zhang F, Guo X, Wu S, Han J, Liu Y, Shen H. Genome-wide pathway association studies of multiple correlated quantitative phenotypes using principle component analyses. PLoS ONE. 2012 Dec;7(12):e53320(SCI,IF: 3.79)
13. Zhang F, Guo X, Wang WZ, Ma WJ, Wu SX, Yan H. Expression profile analysis of mycotoxin-related genes in cartilage with endemic osteochondropathy kashin-beck disease. BMC Musculoskeletal Disorders. 2012, Jul; 13:130(SCI,IF: 1.87)
14. Zhang F, Wang Y, Deng HW. Comparison of population-based association study methods correcting for population stratification. PLoS ONE. 2008 Oct;3(10):e3392.(SCI,IF: 4.35)
15. Zhang F. Correcting for cryptic relatedness in population-based association studies. Human Heredity. 2010;69(1):28-33.(SCI,IF: 2.24)
16. Zhang F, Liu J, et.al. HAPSIMU: a genetic simulation platform for population-based association studies. BMC Bioinformatics. 2008 Aug 5;9:331.(SCI,IF: 3.78)
17. Zhang F, Xiong DH, et.al. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. Biochem.Biophys.Res.Commun.2006 Oct; 348(4):1378-1382.(SCI,IF: 2.55)
18. Zhang F, Zhang L, Deng HW. A PCA-based method for ancestral informative markers selection in structured populations. Science in China: Life Sciences. 2009 Oct;52(10):972-976.(SCI,IF: 2.02)
19. Guo Y, Tan LJ, Lei SF, Yang TL, Chen XD, Zhang F, Chen Y, Pan F, Yan H, Liu X, Tian Q, Zhang ZX, Zhou Q, Qiu C, Dong SS, Xu XH, Guo YF, Zhu XZ, Liu SL, Wang XL, Li X, Luo Y, Zhang LS, Li M, Wang JT, Wen T, Drees B, Hamilton J, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW. Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet. 2010 Jan 8;6(1):e1000806.(SCI,IF: 9.54),
20. Zhang YG, Zhang F, Sun ZM, Guo WT, Liu J, Liu M, Guo X. A controlled case study of the relationship between environmental risk factors and apoptotic gene polymorphism and lumbar disc herniation. American Journal of Pathology. American Journal of Pathology. 2013 Jan;182(1):56-63.(SCI,IF: 4.89)
21. Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ. Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthritis Cartilage. 2014 pii: S1063-4584(14)01196-0(SCI,IF: 4.66)
22. Wen Y, Zhang F, Li C, He S, Tan W, Lei Y, Zhang Q, Yu H, Zheng J, Guo X. Gene expression analysis suggests bone development-related genes GDF5 and DIO2 are involved in the development of Kashin-Beck disease in children rather than adults. PLoS One. 2014 Jul 29;9(7):e103618(SCI,IF: 3.53)
23. Wang S, Duan C, Zhang F, Ma WJ, Guo X. Regulatory gene networks and signaling pathways from primary osteoarthritis and Kashin-Beck disease, an endemic osteoarthritis, identified by three analysis software. Gene. 2013 Jan, 512(1),89-96. (SCI,IF: 2.34)
24. Wu SX, Wang WZ, Zhang F, Wu CY, Dennis BS, Qu CJ, Bai YD, Guo X. Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis. Gene. 2013 Dec, 1119(13)01576-X(SCI,IF: 2.34)
25. He SL, Tan WH, Zhang ZT, Zhang F, Qu CJ, Lei YX, Zhu YH, Yu HJ, Xiang YZ, Guo X. Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy. Exp Cell Res. 2013 Oct 15;319(17):2604-16(SCI,IF: 3.55).
26. Zhang, LS, Guo, YF, Liu, YZ, Liu, YJ , Xiong, DH, Liu, XG, Wang, LA , Yang, TL , Lei, SF, Guo, Y , Yan, H, Pei, YF, Zhang, F , Papasian, CJ, Recker, RR, Deng, HW. Pathway-Based Genome-Wide Association Analysis Identified the Importance of Regulation-of-Autophagy Pathway for Ultradistal Radius BMD. J Bone Miner Res. 2010 Jul;25(7):1572-80. (SCI,IF: 6.13)
27. Han J, Guo X, Tan W, Zhang F, Liu J, Wang W, Xu P, Lammi MJ.The expression of p-ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin-Beck disease. BMC Musculoskelet Disord. 2013 Jul 16;14(1):209 (SCI,IF: 1.87)
28. Wang X, Wang S, He S, Zhang F, Tan W, Lei Y, Yu H, Li Z, Ning Y, Xiang Y, Guo X. Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China. Sci China Life Sci. 2013 Sep;56(9):797-803.(SCI,IF: 1.51).
29. Li CY, Wang WZ, Guo X, Zhang F, Ma WJ, Zhang YG, Li YF, Bai YD, LAMMI Mikko. Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China. Sci China Life Sci.. 2012 Nov, 55(12),1057-1063.(SCI,IF: 1.69).
30. Chen Y, Xiong DH, Guo YF, Pan F, Zhou Q, Zhang F, Deng HW.Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry. Bone. 2010 Jan;46(1):129-136.(SCI,IF: 4.60)
31. Zhang YP, Liu YZ, Guo Y, Liu XG, Xu XH, Guo YF, Chen Y, Zhang F, Pan F, Zhu XZ, Deng HW. Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures. PLoS One. 2011;6(7):e21835. (SCI,IF: 4.35)
32. Zhang YP, Deng FY, Yang TL, Zhang F, Chen XD,Shen H, Zhu XZ, Tian Q. Genome-Wide Association Study Identified CNP12587 Region Underlying Height Variation in Chinese Females. PLoS ONE. 2012,Sep;7(9): e44292. (SCI,IF:4.03)
33. Zhang ZX, Lei SF, Deng FY, Zhang F, Liu YJ, Recker RR, Papasian CJ, Deng HW. Bivariate genome-wide linkage analysis for traits BMD and AAM: Effect of menopause on linkage signals. Maturitas. 2009 Jan 20;62(1):16-20.(SCI,IF: 2.09)
34. Yang F, Xiong DH, Guo Y, Shen H, Xiao P, Zhang F, Jiang H, Recker RR, Deng HW. The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. Human Genetics. 2007 Mar;121(1):35-42.(SCI,IF: 3.97)
35. Jiang H, Xiong DH, Guo YF, Shen H, Xiao P, Yang F, Chen Y, Zhang F, Recker RR, Deng HW. Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families. International Journal of Obesity. 2007 Aug;31(8):1319-1324.(SCI,IF: 3.56)
36. Chen Y, Xiong DH, Yang TL, Yang F, Jiang H, Zhang F, Shen H, Xiao P, Recker RR, Deng HW. Variations in RANK gene are associated with adult height in Caucasians. American Journal of Human Biology. 2007 Jul-Aug;19(4):559-565.(SCI,IF:1.80)
37. He LN, Xiong DH, Liu YJ, Zhang F, Recker RR, Deng HW. Association study of the oestrogen signalling pathway genes in relation to age at natural menopause. Journal of genetics. 2007 Dec;86(3):269-276.(SCI,IF: 0.76)

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